Nanotechnology-based drug delivery for targeted therapy of autoimmune arthritis improves the therapeutic profile of anti-arthritis drugs
نویسندگان
چکیده
Abstract Rheumatoid arthritis (RA) is among the major human autoimmune diseases, and it affects over 1 percent of population. Although many anti-arthritis drugs are available for RA therapy, their long-term use may lead to severe adverse effects. This, combined with high cost newer drugs, poses a hurdle effective control as well patient compliance therapeutic regimens. Therefore, novel treatment modalities required overcome these limitations. In this context, we have developed nanotechnology-based drug delivery system targeted therapy arthritic inflammation. Liposomal entrapment increases shelf-life in vivo, whereas display joint-homing peptide ligand on liposomal surface aids guiding them site One such (denoted ART-1) was previously identified by us phage peptide-display library screening Lewis rats. When administered subcutaneously or intravenously, fluorescence-labeled ART-1 shows preferential homing joints compared normal (control) joints. We exploited experimental dexamethasone (Dex) using rat adjuvant (AA) model. At time onset AA, rats were treated Dex, unpackaged (free) vehicle alternate days. All observed graded regularly severity. Sera obtained at terminal step tested panel enzymes indicating tissue/organ toxicity. Dex showed improved profile (efficacy/toxicity ratio) that free Dex. propose ligand-targeted approach can be adapted RA. "Supported grants from NIH (R01 AT004321), Veterans Affairs (5 I01 BX002424) Silo Pharma"
منابع مشابه
RNA nanotechnology breakthrough for targeted release of RNA-based drugs using cell-based aptamers
Nucleic acids play different roles besides storing information and proteins coding. For example, single-stranded nucleic acids can fold into complicated structures with capability of molecular detection, catalyzing bioreactions and therapy. The development of RNA-based therapies has been rapidly progressed in the recent years. RNA aptamers are biomolecules with a size of 10 to 50 nm that can be...
متن کاملassessment of the effect of honey as a topical therapy for intra oral wound healing in rat.
چکیده ندارد.
15 صفحه اولBone mineral density changes during treatment of rheumatoid arthritis with disease-modifying-anti-rheumatic drugs
Background: Bone mineral density (BMD) changes during the course of rheumatoid arthritis (RA). The present study was designed to investigate the status of BMD in patients with RA treated with anti-rheumatic drugs. Methods: BMD at the femoral neck (FN-BMD) and lumbar spine (LS-BMD) were measured by dual energy x-ray absorptiometry (DXA) method using Norland densitometer. Disease activity (DA) wa...
متن کاملAlbumin-based drug delivery as novel therapeutic approach for rheumatoid arthritis
We reported recently that albumin is a suitable drug carrier for targeted delivery of methotrexate (MTX) to tumors. Due to pathophysiological conditions in neoplastic tissue, high amounts of albumin accumulate in tumors and are metabolized by malignant cells. MTX, covalently coupled to human serum albumin (MTX-HSA) for cancer treatment, is currently being evaluated in phase II clinical trials. ...
متن کاملNanotechnology-based drug delivery systems
Nanoparticles hold tremendous potential as an effective drug delivery system. In this review we discussed recent developments in nanotechnology for drug delivery. To overcome the problems of gene and drug delivery, nanotechnology has gained interest in recent years. Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery ap...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.165.14